In other words, most forms of resveratrol supplementation are not well absorbed by your body, and therefore its potential health benefits are blunted. My search (on December 3, 2019) from the database of the new shows that there are 162 clinical trials involving resveratrol that aim to investigate the pharmacological activity of resveratrol in treating cancer, diabetes, obesity, and other cardiovascular and neurodegenerative diseases.īut there’s a problem with resveratrol - all of the therapeutic benefits attributed to it are encumbered by its low bioavailability.
A large number of preclinical studies have proved that resveratrol could impact a variety of the diseases that many of us are afflicted with.
Īpparently, the French were on to something. This is an apparent contradiction to the widely held belief that the high consumption of saturated fats is a risk factor for heart disease. Resveratrol became well known for its “ French Paradox”, a catchphrase first used in the late 1980s, that summarizes the apparently paradoxical observation that French people have a relatively low incidence of heart disease, while having a diet relatively rich in saturated fats.
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Resveratrol is concentrated in the skin and seeds of these plants, and has a remarkable range of biological activities, such as anticancer, cardioprotective, neuroprotective and antioxidant properties. Resveratrol is a stilbenoid, a type of natural phenol, which is mildly toxic and produced by numerous plants in response to ultraviolet radiation, injury, fungal or bacterial infection. Nonetheless, various sirtuin-activators, such as resveratrol, its cousin pterostilbene, and the NAD-precursors NMN and NR, have become very popular supplements to the anti-aging crowd, of which I’m an unrepentant member. Studies on how activating sirtuins might increase human lifespan are less clear. Recently, as described by a 2019 study that looked at sirtuins on cellular senescence and aging, sirtuins have been shown to increase lifespan in some organisms (mainly yeast, worms and flies), and resveratrol has been shown to activate them. In the intervening years, much more research has been done on sirtuins and resveratrol. For reasons as clear as mud, apparently, Glaxo and Sirtis couldn’t make good on the investment aimed at creating a resveratrol-like drug that activated sirtuins. David Sinclair, a geneticist at Harvard Medical School, headed studies that indicated resveratrol and related compounds can activate sirtuins. Glaxo shut down the company nearly five years after its acquisition. Sirtis sought to make drugs that act on sirtuins, a class of proteins that scientists believe play a role in aging, programmed cell death, and other key cell processes. So promising was resveratrol that, as reported by life sciences journalist Luke Timmerman, the pharmaceutical giant GlaxoSmithKline paid $720 million to acquire Sirtis Pharmaceuticals, the one-time hot biotech with a plan to fight diseases of aging. Some studies showed that it conferred sufficient health benefits among animals cohorts - even extending the lifespans of some. There’s been much written about resveratrol over the past few years. I want to tell you all about trans-resveratrol, but we need to begin with the plain vanilla variety, resveratrol.